I think the owner's manual discourages fuel injector cleaners, and also seem to remember Jeff Dorge echoing that. I use Chevron Techron in the Sequoia every 5K oil change, but don't do it in the S22.
Pretty common formula's been repeated here for years: boat runs rough, epicmarine recommends plugs, owner replaces plugs, owner reports back success.
Not sure exactly which wire you're talking about, but the only fused one in mine is the dash computer power supply. The problem with even the stock-size wire is not heating, it's excessive voltage loss which causes low-voltage alarms, etc. at the gauges. Doubt it has any effect on engine smoothness.