just thought I'd chime in. repeat after me "I will never put anything other than Denso plugs in my Toyota-----EVER------ " epic, car, truck, suv. Toyotas love factory plugs.? By the way Toyota and Lexus dealerships have denso's cheaper than any worthless autozone could ever have. Plus they are pregapped for your engine. That includes regular, platnium, and irridium plugs. If you go to the dealerships just ask for plugs for a 2000 GS400 or LS400. By the way do not wait for Knocking or pinging to get worse. Normally the Knock sensors detects Knocking or ping well before you can hear it and the ECM retards the timing, that equals a big loss of power. If the ECM cannot retard timing anymore you can then actually hear it Knock or ping and IT WILL DAMAGE your engine. So if you can already hear it Knocking change the plugs NOW!!! and only run premium fuel. Also when changing plugs always apply antiseize to the threaded portion of the plug.